What is the role of G6PD screening in the evaluation of hemolytic anemia?

Updated: May 27, 2021
  • Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

A G6PD screening can usually detect deficiency of this enzyme, but results can be normal if the reticulocyte count is elevated (reticulocytes contain a considerable amount of G6PD). A positive Heinz body preparation can suggest denatured hemoglobin and thus G6PD deficiency (see the image below).

Supravital stain in hemoglobin H disease reveals H Supravital stain in hemoglobin H disease reveals Heinz bodies (golf ball appearance).

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