What is the role of cold agglutinin titer measurement in the workup of hemolytic anemia?

Updated: May 27, 2021
  • Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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The cold agglutinin titer will be elevated in cold agglutinin disease, with the specific IgM antibody varying according to the underlying disorder. For example, a high titer of anti-I antibody (ie, antibody directed against the I antigen found on normal adult RBCs) occurs in mycoplasmal infections. High titers of anti-i antibody (antibody directed against the i antigen found on fetal cord blood RBCs) have been reported in infectious mononucleosis. An anti-P cold agglutinin may be seen in paroxysmal cold hemoglobinuria.

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