What is the Cotswolds modification of the Ann Arbor staging system of diffuse large B-cell lymphoma (DGBCL)?

Updated: Dec 10, 2019
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

Table. Cotswolds modification of Ann Arbor staging system (Open Table in a new window)

Stage

Area of Involvement

I

Single lymph node group

II

Multiple lymph node groups on same side of diaphragm

II

Multiple lymph node groups on both sides of diaphragm

IV

Multiple extranodal sites or lymph nodes and extranodal disease

X

Bulk > 10 cm

E

Extranodal extension or single isolated site of extranodal disease

A/B

B symptoms: weight loss > 10%, fever, drenching night sweats