What is the Revised-International Staging System (R-ISS) for multiple myeloma?

Updated: Sep 12, 2018
  • Author: Mohammad I Abu Zaid, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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R-ISS stages are as follows:

  • Stage I: ISS stage I and  standard-risk chromosomal abnormalities by fluorescence in situ hybridization (FISH)(ie, no high-risk) and serum lactate dehydrogenase (LDH) level at or below the upper limit of normal
  • Stage II: Not R-ISS stage I or III
  • Stage III: ISS stage III and  either high-risk chromosomal abnormalities by FISH (ie, presence of del(17p) and/or translocation t(4;14) and/or translocation t(14;16)) or serum LDH level above the upper limit of normal

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