What are the diagnostic criteria for smoldering multiple myeloma?

Updated: Sep 12, 2018
  • Author: Mohammad I Abu Zaid, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

To meet the definition of smoldering multiple myeloma, both of the following criteria must be met:

  • Serum monoclonal protein (IgG or IgA) ≥30 g/L or urinary monoclonal protein ≥500 mg per 24 h and/or clonal bone marrow plasma cells 10–60%
  • Absence of myeloma-defining events or amyloidosis

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