What are treatment recommendations for synovial sarcoma?

Updated: Apr 29, 2019
  • Author: from Memorial Sloan-Kettering - Mrinal M Gounder, MD; Chief Editor: Edwin Choy, MD, PhD  more...
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Answer

Answer

Chemosensitive disease with particular sensitivity to ifosfamide

A case series of 13 patients with synovial sarcoma treated with high-dose ifosfamide showed response in all patients, with four CRs achieved. [38]

A single-institution study of 100 patients treated with doxorubicin and/or ifosfamide showed a median survival of 22 mo; single-agent doxorubicin or ifosfamide achieved responses in 25% of patients treated, but combination therapy achieved a response rate of 58%. [39]


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