What are treatment recommendations for leiomyosarcoma?

Updated: Apr 29, 2019
  • Author: from Memorial Sloan-Kettering - Mrinal M Gounder, MD; Chief Editor: Edwin Choy, MD, PhD  more...
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Answer

Answer

A phase II study randomized patients with leiomyosarcomas to gemcitabine (1200 mg/m2 IV on days 1 and 8; every 21 d) alone or gemcitabine (900 mg/m2 IV over 90 min on days 1 and 8) and docetaxel (100 mg/m2 IV over 90 min on day 8; every 21 d) and reported higher response rates in the dual chemotherapy arm (32% vs 27%), with a 3% complete response (CR) and significantly improved progression-free survival (6.3 vs 3 mo). [30]

Several phase II trials have demonstrated the activity of temozolomide in sarcoma, with efficacy particularly notable in leiomyosarcoma. [31, 32]

Temozolomide can be administered as a 6-wk, continuous oral schedule at a dose of 75 mg/m2 or BID on a 12-h schedule for 5 d as an oral bolus dose of 200 mg/m2 followed by 9 doses of 90 mg/m2 every 4 wk.


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