What is the role of preoperative for X-ray therapy (XRT) in the treatment of soft tissue sarcoma?

Updated: Apr 29, 2019
  • Author: from Memorial Sloan-Kettering - Mrinal M Gounder, MD; Chief Editor: Edwin Choy, MD, PhD  more...
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Preoperative XRT:

  • Benefits of using preoperative therapy are that large tumors adjacent to critical organs may become resectable; a smaller treatment field is needed; and potentially less tumor seeding may occur during resection

  • The common dose for XRT is 50 Gy

  • Negative aspects of using this therapy include increased wound-healing complications [7, 8]

  • If margins are close (< 1 cm) or positive, consider boost with brachytherapy, intraoperative radiation therapy (IORT), or postoperative XRT/intensity modulated radiation therapy (IMRT) at doses ranging from 10-26 GY [9]

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