What are the concurrent chemotherapy/radiation therapy regimens for non-small cell lung cancer (NSCLC) stage III?

Updated: Mar 08, 2021
  • Author: Marvaretta M Stevenson, MD; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Answer

Answer

Acceptable chemotherapy regimens for use in concurrent chemotherapy/radiation therapy are as follows:

  • Cisplatin 50 mg/m2 IV on days 1, 8, 29, and 36 plus  etoposide 50 mg/m2 IV on days 1-5 and days 29-33 [13, 14, 15, 16, 17] or

  • Cisplatin 100 mg/m2 IV on days 1 and 29 plus  vinblastine 5 mg/m2/weekly IV for 5 wk [7, 18] or

  • Carboplatin AUC 2 IV weekly for 7 wk plus  paclitaxel 50 mg/m2 IV weekly for 7 wk; 3 wk later, it can be followed by two cycles of consolidation chemotherapy with carboplatin AUC 6 IV on day 1 plus  paclitaxel 200 mg/m2 IV on day 1 every 21 wk [19, 20] or

  • Carboplatin AUC 5 IV on day 1 plus  pemetrexed 500 mg/m2 IV on day 1 every 21 d for four cycles [21] or

  • Cisplatin 75 mg/m2 IV on day 1 plus pemetrexed 500 mg/m2 IV on day 1 every 21 d for three cycles [22]


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