What is the Follicular Lymphoma global Prognostic Index (FLIPI) score?

Updated: Feb 11, 2020
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

The development and validation of an accurate and easily available prognostic index for FL has facilitated the development of treatment algorithm plans, enabled the cross-talk between investigators, and improved understanding of the results of clinical studies.

Briefly, the FL International Prognostic Index (FLIPI) score was designed by studying clinical characteristics of 1795 newly diagnosed cases of FL between 1985 and 1992 across 27 different cancer centers. Several clinical parameters known to affect the outcome of FL patients were tested in the patient population using a univariate and multivariate analysis. The statistical analysis identified 5 variables that strongly and independently were associated with a poor clinical outcome, as provided below. [3]

Factors (1 point for each variable present) [3] :

  • Age > 60y

  • Ann Arbor Stage III-IV

  • Hemoglobin level < 12 g/dL

  • Lactate dehydrogenase (LDH) level > upper limit of normal (ULN)

  • ≥ 4 nodal sites of disease

Risk category (factors) [3] :

  • Low risk (0 or 1)

  • Intermediate risk (2)

  • High risk (> 3)


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