Which regimens are used for maintenance therapy in multiple myeloma?

Updated: Aug 14, 2019
  • Author: Sara J Grethlein, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Meta-analysis suggests benefit in progression-free survival (PFS) and overall survival with lenalidomide maintenance therapy. The following regimens have been used successfully:

  • Lenalidomide 10 mg/day on days 1-21 every 28d [34]   or
  • Lenalidomide 10 mg/day

PFS benefit was also observed in a phase III study of bortezomib and ixazomib compared with placebo. These agents can be alternatives to lenalidomide, particularly in patients with lenalidomide intolerance or renal failure. [7] Bortezomib-mediated neuropathy is common with long-term use, however, so patients require close monitoring and dose titration if side effects occur.


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