Which regimens are used for maintenance therapy in multiple myeloma?

Updated: Jul 11, 2019
  • Author: Sara J Grethlein, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Once the best remission has been achieved, maintenance therapy with lenalidomide or thalidomide, with or without steroids, can prolong remission, although not survival. Newer studies are defining the role of bortezomib-based maintenance therapy. [32] The American Society of Hematology has published evidence-based guidelines addressing this question. [33] Regimens are as follows:

  • Lenalidomide 10 mg/day on days 1-21 every 28d [34] or

  • Thalidomide 50 mg/day to start, escalated to 200 mg/day, titrated to tolerance [35]

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