How is relapsed multiple myeloma treated in patients who have received a stem cell transplantation?

Updated: Aug 14, 2019
  • Author: Sara J Grethlein, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

A second autologous stem cell transplant is an option for patients who relapse more than 12 mo after the first transplant (normally, enough cells are collected and cryopreserved for a tandem transplant). Patients who relapse within 12 mo of the initial transplant are best treated with agents they have not received before. Patients who relapse after the second autologous transplant may be candidates for allogeneic transplant or salvage chemotherapy. [13]

Salvage therapy is used in the following [13] :

  • Patients who have relapse following allogeneic or autologous stem cell transplant
  • Patients with primary progressive disease following initial autologous or allogeneic stem cell transplant
  • Patients who are ineligible for stem cell transplant with progressive or relapsing disease after initial induction therapy

Salvage therapy is used in the following [13] :

  • Patients who have relapse following allogeneic or autologous stem cell transplant
  • Patients with primary progressive disease following initial autologous or allogeneic stem cell transplant
  • Patients who are ineligible for stem cell transplant with progressive or relapsing disease after initial induction therapy

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