What are special considerations for chemotherapy to treat ovarian cancer?

Updated: Dec 06, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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Answer

Answer

Elderly patients may not tolerate chemotherapy as well as younger patients.

Comorbid conditions affect tolerance to chemotherapy and necessitate close monitoring and dose reductions; such conditions may include liver or renal dysfunction. Possible regimens include the following:

  • Carboplatin AUC 5 IV plus paclitaxel 135 mg/m2; every 21 d [56] or

  • Paclitaxel 60 mg/m2 over 1 h followed by carboplatin at AUC 2 IV over 30 min; weekly for 18 weeks or

  • Single-agent carboplatin at AUC ≥4-5 IV push; every 21d


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