What are the chemotherapy regimens used in the treatment of stage III ovarian cancer?

Updated: Dec 06, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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Answer

Answer

At this time, there is no standardized regimen for IP therapy; however, the following dosing regimens may be used:

  • Paclitaxel 135 mg/m2 continuous IV infusion over 3 h or 24 h on day 1 plus cisplatin 75-100 mg/m2 IP on day 2 (may reduce dose to 75 mg/m2) plus paclitaxel 60 mg/m2 IP on day 8; repeat every 3 weeks for si6 cycles, provided that the disease is responsive [10]

  • The cisplatin dose may be reduced to 75 mg/m2 IP on day 2; some clinicians give paclitaxel 135 mg/m2 IV over 3 h followed by cisplatin 75 mg/m2 IP, both on day 1 and on an outpatient basis [12]

  • Normal range of carboplatin AUC for treatment of ovarian carcinoma is from 5 to 7.5; patients who have received extensive prior chemotherapy or radiation should start with an AUC < 5

If the patient cannot tolerate IP delivery, revert to one of the following two drug regimens:

  • Paclitaxel 175 mg/m2 IV over 3 h plus carboplatin AUC 5-6 IV over 1 h on day 1; every 21 d for six cycles [13] or

  • Docetaxel 75 mg/m2 IV over 1 h plus  carboplatin AUC 5 IV over 1 h on day 1; every 21 d for six cycles [8]


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