What are the chemotherapy regimens used in the treatment of stage II ovarian cancer?

Updated: Dec 06, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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Answer

Answer

All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection.  These patients should strongly consider participation in clinical trials if the option is available.

  • Paclitaxel 175 mg/m2 IV over 3 h plus  carboplatin AUC 5-6 IV over 30 min on day 1; every 21 d for three to six cycles [7] or

  • Dose-dense paclitaxel 80 mg/m2 IV over 1 hr on days 1, 8, and 15 plus carboplatin AUC 5-6 IV over 1 h on day 1; every 21 d for six cycles or

  • Paclitaxel 60 mg/m2 IV over 1 h followed by carboplatin AUC 2 IV over 30 min; weekly for 18 weeks or

  • Docetaxel 60-75 mg/m2 IV over 1 h plus carboplatin AUC 5-6 IV over 1 h on day 1; every 21 d for three to six cycles  [4]  or

  • Carboplatin AUC 5 IV over 1 h plus pegylated liposomal doxorubicin 30 mg/m2; every 28 d for six cycles [9]


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