What are the chemotherapy regimens used in the treatment of stage I ovarian cancer?

Updated: Dec 06, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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Answer

Answer

Consider chemotherapy for stages 1A and 1B grades 2 and 3, and stage 1C. Chemotherapy is usually given after surgery. Regimens are as follows:

  • Paclitaxel 175 mg/m2 IV over 3 h plus  carboplatin area under the curve (AUC) 5-6 IV (see Carboplatin AUC Dose Calculation [Calvert formula]) over 1 h on day 1; every 21 d for three to six cycles [7] or

  • Docetaxel 60-75 mg/m2 IV over 1 h plus  carboplatin AUC 5-6 IV over 1 h on day 1; every 21 d for three to six cycles [8]  or

  • Carboplatin AUC 5 IV over 1 h on day 1 plus  pegylated liposomal doxorubicin 30 mg/m2 IV up to 1 h; every 28 d for three to six cycles


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