What is the general treatment approach for ovarian cancer?

Updated: Dec 06, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: from Memorial Sloan-Kettering - Yukio Sonoda, MD  more...
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Answer

Answer

Surgery is the initial modality of treatment for stage I-IVA epithelial ovarian cancer. However, only a small percentage of women with epithelial ovarian cancer can be treated with surgery alone. This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. Treatment of grade 2 tumors remains controversial. [3, 4]

High-risk features such as stage IC, higher grade, or clear-cell histology should prompt consideration of adjuvant chemotherapy. [5] Clear-cell carcinomas are associated with a significantly worse prognosis in stage I; all patients with this histologic subtype should be considered for chemotherapy. [6]

Women with any stage of epithelial ovarian cancer should be considered for clinical trials if available.


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