What is the WHO classification of acute lymphoblastic leukemia (ALL)?

Updated: Jul 03, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

The World Health Organization (WHO) classifications [1] and French-American-British (FAB) [2] for acute lymphoblastic leukemia (ALL) are provided below.

WHO classification of acute lymphoblastic leukemia

The WHO classifies ALL as B-lymphoblastic leukemia/lymphoma or T-lymphoblastic leukemia/lymphoma. The 2016 revision includes several provisional entities.

B lymphoblastic leukemia/lymphoma:

  • B-lymphoblastic leukemia/lymphoma, not otherwise specified (NOS)  
  • B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities  
  • B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1  
  • B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged  
  • B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1);  ETV6-RUNX1 
  • B-lymphoblastic leukemia/lymphoma with hyperdiploidy  
  • B-lymphoblastic leukemia/lymphoma with hypodiploidy  
  • B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)  IL3-IGH 
  • B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1 
  • Provisional: B-lymphoblastic leukemia/lymphoma,  BCR-ABL1–like  
  • Provisional: B-lymphoblastic leukemia/lymphoma with  iAMP21

T lymphoblastic leukemia/lymphoma:

  • Provisional: Early T-cell precursor lymphoblastic leukemia
  • Provisional: Natural killer (NK) cell lymphoblastic leukemia/lymphoma

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