What are the contraindications to specific breast cancer treatments?

Updated: Apr 23, 2020
  • Author: Joseph A Sparano, MD; Chief Editor: John V Kiluk, MD, FACS  more...
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Answer

Answer

Certain comorbidities may pose relative or absolute contraindications to specific therapies, including cardiac disease (anthracycline) and neuropathy (taxanes).

Adjustment of prognosis for comorbidity is more complex and is influenced by its severity, time since onset, age of the individual, and other comorbidities.

For patients with significant comorbidities characterized by organ system dysfunction (eg, congestive heart failure, chronic obstructive pulmonary disease, cirrhosis, or chronic renal insufficiency), the prognosis for the comorbidity must be considered in the context of the cancer; the Charlson index is commonly used for this purpose. [64]


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