What are the preferred combination regimens for the treatment of recurrent or metastatic breast cancer?

Updated: Apr 23, 2020
  • Author: Joseph A Sparano, MD; Chief Editor: John V Kiluk, MD, FACS  more...
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Answer

Answer

Regimens are as follows:

  • CAF: Cyclophosphamide 100 mg/m2 IV on day 1 plus  doxorubicin (Adriamycin) 30 mg/m2 IV on days 1 and 8 plus  5-fluorouracil (5-FU) 500 mg/m2 IV on days 1 and 8 every 4 wk for six cycles or

  • FAC: 5-FU 500 mg/m2 IV on days 1 and 8 or days 1 and 4 plus  doxorubicin 50 mg/m2 IV on day 1 plus  cyclophosphamide 500 mg/m2 IV on day 1 every 3 wk for six cycles or

  • FEC: 5-FU 500 mg/m2 IV plus  epirubicin 100 mg/m2 IV plus  cyclophosphamide 500 mg/m2 IV on day 1 every 3 wk for three cycles or

  • AC: Doxorubicin 60 mg/m2 IV plus  cyclophosphamide 600 mg/m2 IV on day 1 every 3 wk for four cycles or

  • EC: Epirubicin 100 mg/m2 IV on day 1 plus  cyclophosphamide 830 mg/m2 IV on day 1 every 3 wk for eight cycles or

  • AT: Doxorubicin 50 mg/m2 IV plus  paclitaxel 125-200 mg/m2 every 3 wk or

  • AT: Doxorubicin 50 mg/m2 IV plus  docetaxel 75 mg/m2 IV every 3 wk or

  • CMF: Cyclophosphamide 100 mg/m2 IV PO on days 1-14 plus  methotrexate 40 mg/m2 IV on days 1 and 8 plus  5-FU 600 mg/m2 IV on days 1 and 8 every 4 wk or

  • Docetaxel/capecitabine: Docetaxel 75 mg/m2 IV on day 1 plus  capecitabine 950 mg/m2 PO BID on days 1-14 every 3 wk or

  • GT: Paclitaxel (Taxotere) 175 mg/m2 on day 1 plus  gemcitabine 1250 mg/m2 IV on days 1 and 8 (following paclitaxel on day 1) every 3 wk


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