How is localized bone disease treated in women with breast cancer?

Updated: Apr 23, 2020
  • Author: Joseph A Sparano, MD; Chief Editor: John V Kiluk, MD, FACS  more...
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Answer

Answer

Local irradiation should be considered for patients with localized bony disease that is symptomatic or at risk for producing a catastrophic complication (eg, spinal cord compression or pathologic fracture).

If expected survival is at least 3 mo and renal function is adequate, any of the following may be given (all with calcium and vitamin D supplementation) on a 3-wk to 5-wk schedule in conjunction with chemotherapy or endocrine therapy [1] :

Original studies continued treatment for up to 2 y; however, there are limited long-term safety data showing that therapy can continue beyond that time. Longer durations of bisphosphonate therapy can potentially provide additional benefits, but this possibility has not been tested in clinical trials. [1, 30, 31]


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