How is early-stage follicular lymphoma (FL) treated?

Updated: Jan 16, 2019
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

Stage I or II, World Health Organization (WHO) FL grade 1 or 2 [4]

Recommendations are as follows:

  • IFRT is the treatment of choice for early-stage disease
  • Radiation doses of 24-30 Gy have been used (36 Gy only if bulky) to involved sites
  • Radiation therapy is preferred for limited-stage FLs; however, if significant toxicity is expected from radiotherapy, initial observation may be more appropriate

First-line treatment recommendations include using rituximab alone, as follows [4] :

  • Rituximab 375 mg/m 2 IV on days 1, 8, 15, and 22; repeat for one additional cycle [5]
  • Clinical study evaluating rituximab with or without biologic agents

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