What are the GELF criteria for immediate follicular lymphoma (FL) treatment?

Updated: Jan 16, 2019
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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GELF criteria are as follows [1] :

  • High tumor bulk (see definition below)
  • Presence of systemic symptoms
  • Eastern Cooperative Oncology Group (ECOG) performance status >1
  • Serum lactate dehydrogenase (LDH) or beta2-microglobulin level above normal values

High tumor bulk is defined with the following parameters:

  • A tumor >7 cm in diameter
  • Three nodes in three distinct areas, each >3 cm in diameter
  • Symptomatic spleen enlargement
  • Organ compression
  • Ascites or pleural effusion

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