When is prophylactic IT chemotherapy indicated in the treatment of diffuse large B-cell lymphoma (DLBCL)?

Updated: Jun 12, 2019
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Prophylactic IT chemotherapy with low-dose methotrexate (eg, 12 mg) should be routinely administered to DLBCL patients with the following characteristics [8, 9] :

  • More than one extranodal site of disease

  • Testicular or breast involvement, regardless of stage

  • Lymphoblastic variants

  • Oropharyngeal or paraspinal sites of involvement

  • Bone marrow involvement

  • Concomitant infection with HIV

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