What are the treatment recommendations for advanced-stage diffuse large B-cell lymphoma (DLBCL)?

Updated: Jun 12, 2019
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Stages III-IV:

  • R+CHOP: Rituximab 375 mg/m2 IV on day 1 plus  cyclophosphamide 750 mg/m2 IV on day 1 or 3 plus  doxorubicin 50 mg/m2 IV on day 1 or 3 plus  vincristine 1.4 mg/m2 (maximum dose, 2 mg) IV on day 1 or 3 plus  prednisone 40 mg/m2 PO on days 1-5 or 3-8; every 21d for 6 cycles with or without IFRT [6, 7]

  • Consider radiation therapy to bulky sites of disease at the end of chemoimmunotherapy

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