What are the NCCN diagnostic guidelines for hairy cell leukemia (HCL)?

Updated: Sep 16, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

According to NCCN guidelines, immunohistochemistry (IHC) and flow cytometry are essential for establishing a diagnosis of HCL and distinuguishing between HCL and hairy cell variant. The recommended tests include the following [15] :

  • Immunohistochemistry (IHC) panel or flow cytometry: CD19, CD20, CD5, CD10, CD11c, CD22, CD25, CD103, CD123, cyclin D1, and CD200
  • IHC for BRAF V600E mutation 

ESMO and HCLF recommendations concur with the above NCCN recommendations. [16, 17]


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