How is accelerated-phase chronic myelogenous leukemia (AP-CML) and blast-phase chronic myelogenous leukemia (BP-CML) treated?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Clinical trials should be recommended to all patients with acclerated-phase CML (AP-CML) and blast-phase CML (BP-CML). Mutation analysis is recommended for all patients with advanced disease prior to initiation of TKI therapy. Patients whose CML progresses to an advanced phase while on TKI therapy have a worse prognosis than those with de novo advanced-phase CML.


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