Which tests are performed when milestones are not achieved or any loss of response to treatment occurs in chronic myelogenous leukemia (CML)?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Bone marrow cytogenetics should be repeated if milestones are not achieved or any loss of response to treatment occurs. QPCR should be done in 1-3 months when there is a 1-log increase in BCR-ABL1 transcripts with MMR. Mutation analysis should be done if there is a 1-log increase in BCR-ABL1 transcripts without MMR. If none of the cytogenetic or molecular milestones are achieved at 3, 6, or 12 months after second-line and subsequent TKI therapy, then alternative therapies or allogeneic HCT are recommended.


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