What are the treatment protocols for chronic myelogenous leukemia (CML) in patients with a cytogenetic response of 1%-35% Ph+?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In patients who had 1%-35% Ph+, results of cytogenetic response measured at 3-months, and recommended treatment strategies, are as follows [19] :

  • Ph+ >0%: Switch to different TKI, clinical trial enrollment, or evaluate for HCT
  • Ph+ 0%: Continue TKI at same dose

 At 12 months, if Ph + >35%, then treatment options are to switch to a different TKI, enroll the patient in a clinical trial, or evaluate for HCT. If Ph + <35%, continue the TKI at the same dose. Monitor for toxicity.

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