What are the treatment protocols for chronic myelogenous leukemia (CML) in patients with a cytogenetic response of 36%-95% Ph+?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

In patients who had 36%-95% Ph+, results of cytogenetic response measured at 3 months, and recommended treatment strategies, are as follows [19] :

  • Ph+ >35%: Switch to different TKI, clinical trial enrollment, or evaluate for HCT
  • Ph+ ≤35%: Continue TKI at same dose

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