What are the treatment protocols for chronic myelogenous leukemia (CML) in patients with a lack of CHR or cytogenetic response of 100% Ph+?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In patients with lack of CHR, or whose cytogenetic response had shown 100% Ph+, results of cytogenetic response measured at 3-months, and recommended treatment strategies, are as follows [19] :

  • Ph+  >65%: Switch to different TKI, clinical trial enrollment, or evaluate for HCT
  • Ph+ ≤65%: Continue TKI at same dose

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