How is complete cytogenetic response monitored in patients with chronic myelogenous leukemia (CML) taking TKIs?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Cytogenetic response is usually done on bone marrow samples in metaphase (at the time of diagnosis and if failure to achieve desired milestones or loss of milestones occurs) and is defined as follows [19] :

  • Complete cytogenetic response (CCyR): Absence of Ph+ cells in metaphase
  • Partial cytogenetic response (PCyR): Presence of Ph+ cells in 1%-35% metaphases
  • Major cytogenetic response: Presence of Ph+ cells in 0%-35% metaphases
  • Minor cytogenetic response: Ph+ >35% metaphases

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