What steps should be taken prior to initiation of TKIs for the treatment of chronic phase chronic myelogenous leukemia (CP-CML)?

Updated: Oct 23, 2019
  • Author: Rossa Khalaf, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

For CP-CML, determination of the patient's Sokal or Hasford risk score is recommended prior to initiation of TKIs. The Sokal score is based on the patient’s age, spleen size, peripheral platelet count, and blast percentage in peripheral blood, while the Hasford score is based on peripheral eosinophil and basophil counts in addition to the Sokal parameters. Either of these scores helps in stratifying patients with CP-CML into low, intermediate, or high risk, which will guide the choice of TKI. [16, 17] In addition to the risk score, the toxicity profile of theTKI and patient comorbidities guide the choice of therapy.


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