What are the clinical variants of symptomatic plasma cell myeloma?

Updated: Oct 14, 2019
  • Author: Lesley Elizabeth Fox, MD; Chief Editor: Francis H Gannon, MD  more...
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Answer

Answer

Symptomatic plasma cell myeloma has the following related clinical variants and features [1] :

  • Asymptomatic plasma cell myeloma: Absence of end-organ damage

  • Nonsecretory plasma cell myeloma: Absence of monoclonal protein on immunofixation (IFE)

  • Plasma cell leukemia: Increase in circulating clonal plasma cells greater than 20% of the leukocyte count or greater than 2.0 × 109 cells/L


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