What are the response criteria for acute promyelocytic leukemia (APL) treatment?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

See the list below:

  • Complete remission (CR): bone marrow blasts < 5% in aspirate with spicules, no evidence of extramedullary disease, transfusion independence, PCR negative, absolute neutrophil count (ANC) > 1000/µL (see the Absolute Neutrophil Count calculator) with platelet count > 100,000/µL

  • CR with incomplete blood count recovery (CRi) or incomplete platelet count recovery (CRp): CR plus persistence of cytopenia (eg, underlying myelodysplastic syndrome [MDS] in the elderly)

  • Partial remission (PR) or treatment failure: 5-25% blasts in bone marrow or 50% decrease in blasts and normalization of blood counts


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