How is acute promyelocytic leukemia (APL) relapse treated?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

See the list below:

  • If the European APL regimen or the PETHEMA regimen was used initially, use ATO induction and consolidation doses for treatment of relapse. [11]

  • If molecular remission is achieved with salvage therapy, the patient should be considered for autologous stem cell transplantation. [12]

  • If persistent molecular or hematologic disease is noted after salvage therapy, the patient should be considered for allogeneic stem cell transplantation if performance status is good and a human leukocyte antigen (HLA)–matched donor is available. [13]

  • If ATO was used initially, consider a clinical trial or supportive care


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