What is included in maintenance therapy for acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

After consolidation therapy, patients should be evaluated for molecular remission. For patients in whom PCR evaluation is negative, a combination of ATRA, 6-mercaptopurine (6-MP), and methotrexate is recommended. Current evidence suggests that maintenance therapy may not provide a significant benefit for patients who have molecular remission after consolidation therapy. The recommended maintenance regimen is 2y of the following [5] :

  • ATRA 45 mg/m 2/day for 15d every 3mo  plus
  • 6-MP 60 mg/m 2/day PO  plus
  • Methotrexate 20 mg/m 2 PO weekly

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