What is the European LeukemiaNet consolidation therapy regimen for the treatment of acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

European LeukemiaNet regimen

  • For patients treated with chemotherapy-free induction regimens: Four courses of ATO (0.15 mg/kg/day 5 days per week, 4 weeks on 4 weeks off)  seven courses of ATRA (45 mg/m per day for adults; 25 mg/m 2 per day for children, 2 weeks on 2 weeks off) are recommended.
  • For patients treated with conventional ATRA plus chemotherapy: Two to three courses of anthracycline-based chemotherapy
  • The addition of ATRA to chemotherapy in consolidation seems to provide a clinical benefit
  • Consolidation for high-risk patients younger than 60 years with WBC counts > 10 x 10 9/L should include at least one cycle of intermediate or high-dose cytarabine
  • Molecular remission in the bone marrow should be assessed at completion of consolidation by reverse transcriptase polymerase chain reaction (RT-PCR) assay with a sensitivity of at least 1 in 10 4.

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