What is the European APL consolidation therapy regimen for the treatment of acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

European APL regimen:

  • First cycle: daunorubicin 60 mg/m2/day IV as 15-30min infusion on days 1-3 plus  cytarabine 200 mg/m2/day IV as 24h infusion on days 1-7

  • Second cycle: daunorubicin 45 mg/m2/day IV as 15-30min infusion on days 1-3 plus  cytarabine 1 g/m2 every 12h on days 1-4

  • ATRA administered concurrently with cycles above: ATRA 45 mg/m2/day (25 mg/m2/day for patients < 20y) in 2 divided doses for 15d with each 4-wk cycle of chemotherapy (especially for intermediate- and high-risk patients)


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