What is the European APL induction therapy regimen for the treatment of acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

European APL regimen:

  • Daunorubicin 60 mg/m 2/day IV as 15-30min infusion for 3d  plus
  • Cytarabine 200 mg/m 2/day IV as 24h continuous infusion on days 1-7 [8, 9]   plus
  • ATRA 45 mg/m 2/day (25 mg/m 2/day for patients < 20y) in 2 divided doses (ATRA is started on day 1)<
  • For high-risk patients, the evidence favors the European APL regimen because it includes cytarabine [8]

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