What is the Programa para el Tratamiento de Hemopatias Malignas (PETHEMA) regimen in induction therapy for acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

PETHEMA regimen:

  • Idarubicin 12 mg/m2 IV bolus on days 2, 4, 6, and 8 (hold 8th dose in patients > 70y) plus

  • ATRA 45 mg/m2/day (25 mg/m2/day for patients < 20y) in 2 divided doses (ATRA is started on day 1)


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