What are treatment recommendations for acute myeloid leukemia (AML) in patients 60 years or older?

Updated: Dec 05, 2018
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

There is no standard therapy for this patient population; a clinical trial is preferred

The following low-intensity therapies are recommended for patients ≥60y: azacytidine 75 mg/m2 IV or SC for 7d every 4-5wk or decitabine 20 mg/m2 IV daily for 5d every 4-5wk or low-dose cytarabine 20 mg SC BID for 10d every 4wk

In patients with a high WBC count (especially >30,000/μL) who are unlikely to respond to low-intensity therapy, consider therapies as in younger patients; however, tolerance and response may be poor


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