Which genetic factors affect the prognosis of acute lymphoblastic leukemia (ALL)?

Updated: Jul 02, 2021
  • Author: Karen Seiter, MD; Chief Editor: Matthew C Foster, MD  more...
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Answer

Answer

Cytogenetics for ALL [42, 43, 44] :

  • Patients with ALL can have abnormalities of chromosome number as well as balanced translocations.

  • Patients with a normal karyotype and those with isolated 9p/CDKN2A-CDKN2B deletions have had a relatively favorable (standard) prognosis.

  • Patients with 6q deletions, miscellaneous karyotype, and hyperdiploid karyotype have had an intermediate prognosis.

  • Patients with t(9;22)/BCR/ABL1, t(4;11)/MLL/AF4, and t(1;19)/TCF3/PBX1 have had an unfavorable prognosis.

  • Previously, t(9;22)(q34;q11) was considered high risk; however, outcomes have improved considerably with the addition of TKIs targeting BCR-ABL to chemotherapy.


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