Which factors affect the prognosis of acute lymphoblastic leukemia (ALL)?

Updated: Oct 23, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

Prognostic factors for ALL include age older than 30 y (worse with increasing age)

White blood cells (WBC) >30,000/mm3 for B-cell ALL; WBC >100,000/mm3 for T-cell ALL

For precursor B-cell ALL, the prognosis is worse for CD10-negative (common ALL antigen [CALLA]-negative) cases

For precursor T-cell ALL, the prognosis is worse for pro-, pre-, and mature-T subtypes (CD1a-, CD3-/CD3+), compared with the CD1a+ cortical/thymic phenotype


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