Which factors affect the prognosis of acute lymphoblastic leukemia (ALL)?

Updated: Jul 02, 2021
  • Author: Karen Seiter, MD; Chief Editor: Matthew C Foster, MD  more...
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Answer

Answer

Immunophenotype for ALL [14, 40, 41] :

  • Prognostic factors for ALL include age older than 30 y (worse with increasing age)

  • White blood cells (WBC) > 30,000/mm3 for B-cell ALL; WBC > 100,000/mm3 for T-cell ALL

  • For precursor B-cell ALL, the prognosis is worse for CD10-negative (common ALL antigen [CALLA]-negative) cases

  • For precursor T-cell ALL, the prognosis is worse for pro-, pre-, and mature-T subtypes (CD1a-, CD3-/CD3+), compared with the CD1a+ cortical/thymic phenotype


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