What are the protocols on blood bank support in the treatment of acute lymphoblastic leukemia (ALL)?

Updated: Oct 23, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

Patients should receive leukodepleted, irradiated blood products to reduce the risk of transfusion-associated graft versus host disease, cytomegalovirus (CMV) transmission, and febrile transfusion reactions

Most patients are anemic and require red cell transfusion support

Patients usually receive packed red cells when the hemoglobin level falls below 8 g/dL

Patients with significant respiratory and cardiac disease might require transfusion at a higher hemoglobin level

Patients are frequently thrombocytopenic; platelet transfusions are indicated when the platelet count is <10,000/mm3

Patients being seen less than daily will receive platelet transfusions at a higher threshold (20,000/mm3)

Patients with active bleeding will be transfused to a platelet count of 50,000/mm3; patients with CNS hemorrhage should be transfused to a platelet count of 100,000/mm3


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