How are infections treated in acute lymphoblastic leukemia (ALL)?

Updated: Jul 02, 2021
  • Author: Karen Seiter, MD; Chief Editor: Matthew C Foster, MD  more...
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Answer

Answer

Treatment of infections:

  • Most patients are neutropenic and immunocompromised.

  • Afebrile patients usually receive prophylactic antibiotics, such as ciprofloxacin (or levofloxacin) and acyclovir (or valacyclovir), and an azole antifungal (posaconazolevoriconazoleitraconazole, or fluconazole) during induction therapy.

  • Febrile neutropenic patients require prompt initiation of broad-spectrum antibiotics.

  • Suggested regimens include a third- or fourth-generation cephalosporin or carbapenem with or without vancomycin.

  • Antibiotics can be modified based on response to therapy; additional antibiotics might be needed for resistant organisms (eg, vancomycin-resistant enterococci [VRE]) or suspected fungal infections.


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