How is tumor lysis syndrome treated in acute lymphoblastic leukemia (ALL)?

Updated: Oct 23, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

Patients with ALL are at risk for tumor lysis syndrome

High-risk factors include elevated WBC count, especially >50,000/mm3; marked elevation of LDH, especially >1000 U/L; baseline hyperuricemia; and baseline renal dysfunction

Patients should receive aggressive hydration and allopurinol; high-risk patients should also receive uricolytic agents (ie, rasburicase)


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