Which regimens are used to treat acute lymphoblastic leukemia (ALL) in adolescent and young adults (AYAs)?

Updated: Oct 23, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

See the list below:

  • The prognosis of ALL is dramatically better in children than in adults.

  • It is unclear to what degree this difference is due to intrinsic differences in the leukemic cells that occur in these two populations versus the intensity of therapy given.

  • Older patients have poor tolerance of high-dose therapies, and as such, many of the regimens designed for adults are less intensive than those given in children. However, younger adults, particularly those younger than 39 y, are able to tolerate similar doses as children.

  • For this reason, clinical trials are now ongoing to determine whether the prognosis of ALL in adults can be improved by giving pediatric-style regimens in the younger-adult population. [16, 17, 18]

Pediatric-style chemotherapy regimens:

  • GRAALL-2003 [19]

  • COG AALL-0434 [20]

  • CCG-1961 [21]

  • CALGB 10403 [22]

  • DFCI regimen [23]


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