Which regimen has improved the prognosis of mature B-cell acute lymphoblastic leukemia (ALL)?

Updated: Oct 23, 2019
  • Author: Karen Seiter, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Answer

See the list below:

  • Mature B-cell ALL is characterized by a high proliferative index, very high LDH, and strong CD20 positivity

  • The prognosis of mature B-cell ALL is poor when disease is treated with traditional ALL regimens

  • However, the prognosis has improved with the use of cyclical dose-dense chemotherapy that includes rituximab and aggressive intrathecal prophylaxis [15]


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