What are the treatment recommendations for Philadelphia chromosome–negative acute lymphoblastic leukemia (ALL) in adults 40 years or older?

Updated: Jul 02, 2021
  • Author: Karen Seiter, MD; Chief Editor: Matthew C Foster, MD  more...
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Philadelphia chromosome–negative (Ph-) ALL in the older adult (age ≥40 y):

  • Standard multiagent chemotherapy regimen (eg, CALGB 8811 [daunorubicin, vincristine, prednisone, pegaspargase, cyclophosphamide])

  • Consider dosage reduction in patient ≥60 y (evaluate end-organ reserve, end-organ dysfunction, and performance status) or with substantial comorbidities

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